A Case of Myelin Oligodendrocyte Glycoprotein Antibody Disease Associated With Post-Dengue Transverse Presenting With Paraplegia and Urinary Retention

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Citations: 22
Date: 18/07/2025
Abstract: Transverse myelitis is the inflammation of the spinal cord, which causes the is demyelination in a horizontal plane. Dengue virus is known to be associated with transverse myelitis para or post infectiously. Autoantibodies such as Aquaporin-4 autoantibodies and Myelin oligodendrocyte glycoprotein autoantibodies have been associated with transverse myelitis. However, the exact causal relationship is yet to be determined. We report a case of post-dengue fever transverse myelitis associated with myelin oligodendrocyte glycoprotein antibody disease. A 26-year-old previously healthy young man presented with acute urinary retention and paraplegia. He had a recent history of contracting dengue virus infection. He had a positive serology for antibodies against the dengue virus and imaging showed the inflammation of the spinal cord consistent with transverse myelitis. Further workup demonstrated the presence of Myelin oligodendrocyte glycoprotein autoantibodies. A diagnosis of Myelin oligodendrocyte glycoprotein antibody disease associated with post-dengue transverse myelitis was made. He was treated with high-dose methylprednisolone for 7 days followed by an oral tapping dose over 6 months. Follow-up examination and imaging showed subsequent improvement with complete recovery. Myelin oligodendrocyte glycoprotein antibody disease is a very less understood and rare complication of dengue virus infection. Further studies are required to determine the exact mechanism. Moreover, prompt diagnosis. treatment can result in early recovery and complete remission of the disease.

The Trend of Modifiable Risk Factors of Ischemic Heart Disease in Pakistan from 2000 To 2022

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Citations: 12
Date: 22/07/2025
Abstract: Ischemic Heart Disease is the leading cause of mortality in Pakistan. It is cause by myocardial ischemia. Most cases of myocardial ischemia are as a result of coronary artery atherosclerosis. There are Modifiable and nonmodifiable risk factors of atherosclerosis. Here we discuss the trend of modifiable risk factors in Pakistan from 2000 to 2022. A Secondary analysis was conducted to find the trend of Modifiable risk factors and its relation with ischemic heart disease in Pakistan from 2000 to 2022. For this purpose, Literature review was performed using google scholar and PubMed, Data on trends of these risk factors was obtained from WHO Pakistan website. The trend of modifiable factors of ischemic heart disease, namely Tobacco smoking, Obesity, Alcohol consumption and Hypertension has been increasing in Pakistan, except for Tobacco smoking. Proper preventive measures must be taken to counter this specific death rate. This may include mass Health education, Health promotion, Dietary changes, and lifestyle changes.

A Case Study: Psychophysiological Impact of Polycystic Ovarian Syndrome and its Management in Pakistani Women

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Citations: 35
Date: 04/07/2025
Abstract: Poly cystic ovary syndrome (PCOS) is a complicated and heterogenous endocrine disorder in the women and it can cause different metabolic, reproductive, and psychological abnormalities and is known for effecting about one among fifteen women globally. PCOS has been frequently diagnosed in women across pakistan and is previously reported to cause different physical and psychological abnormalities like obesity, infertility, hirsutism, depression, and anxiety on a large scale. Irrespective of the higher prevalence still there is inadequacy in the knowledge about PCOS. The aim of this study is to determine the prevalence of different physical and psychological symptoms of PCOS and their co relation with the impact on the quality of life of the affected individual and common methods of treatment used for PCOS. A questionnaire-based study would be designed to collect the data randomly from women of about 17-50 years of age who are affected with PCOS. This questionnaire would be containing all the necessary questions related to the physical and psychological impacts and the treatment methods. This questionnaire-based survey would be analysed by using different statistical analysis tools to provide the complete analytical results. This study will help the medical practioners in the determination of the most prevalent symptoms and can also aid for the improvision in the treatment methods to enhance effectiveness of treatment. It can be used in different educational seminars to spread awareness regarding the symptoms and treatment. It can also aid in further research.